MovDisordV3, Main, Exploration, bibRecord, 001E23

Callosal tissue loss in multiple system atrophy—A one‐year follow‐up study

Identifieur interne : 001E23 ( Main/Exploration ); précédent : 001E22; suivant : 001E24

Callosal tissue loss in multiple system atrophy—A one‐year follow‐up study

Auteurs : Martina Minnerop [Allemagne] ; Eileen Lüders [États-Unis] ; Karsten Specht [Norvège] ; Jürgen Ruhlmann [Allemagne] ; Nicole Schimke [Allemagne] ; Paul M. Thompson [États-Unis] ; Yi Y. Chou [États-Unis] ; Arthur W. Toga [États-Unis] ; Michael Abele [Allemagne] ; Ullrich Wüllner [Allemagne] ; Thomas Klockgether [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-11-15.

RBID : ISTEX:C1E39B42A7766DA05CF4B632D76A808407CBC10D

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Corps calleux, Etude longitudinale, Pathologie du système nerveux.

English descriptors

KwdEn :
- Aged, Atrophy (pathology), Brain Stem (pathology), Cerebellum (pathology), Corpus Callosum (pathology), Corpus callosum, Female, Follow up study, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, MSA, MSA‐C, MSA‐P, Magnetic Resonance Imaging, Male, Middle Aged, Multiple System Atrophy (pathology), Multiple system atrophy, Nervous system diseases, VBM, corpus callosum, follow‐up.
MESH :
- pathology : Atrophy, Brain Stem, Cerebellum, Corpus Callosum, Multiple System Atrophy.
- Aged, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged.

Abstract

Multiple system atrophy (MSA) is a neurodegenerative disease not only affecting the basal ganglia, brainstem, cerebellum, and intermediolateral cell columns of the spinal cord but also the cerebral cortex. Clinically, cerebellar (MSA‐C) and parkinsonian variants of MSA (MSA‐P) are distinguished. We investigated 14 MSA patients (10 MSA‐C, 4 MSA‐P, men: 7, women: 7; age: 61.1 ± 3.3 years) and 14 matched controls (men: 7, women: 7; age: 58.6 ± 5.1 years) with voxel‐based morphometry (VBM) to analyze gray and white matter differences both at baseline and at follow‐up, 1 year later. Baseline comparisons between patients and controls confirmed significantly less gray matter in MSA in the cerebellum and cerebral cortex, and significantly less white matter in the cerebellar peduncles and brainstem. Comparisons of tissue‐loss profiles (i.e., baseline versus follow‐up) between patients and controls, revealed white matter reduction in MSA along the middle cerebellar peduncles, reflecting degeneration of the ponto‐cerebellar tract as a particularly prominent and progressive morphological alteration in MSA. Comparisons between baseline and follow‐up, separately performed in patients and controls, revealed additional white matter reduction in MSA along the corpus callosum at follow‐up. This was replicated through additional shape‐based analyses indicating a reduced callosal thickness in the anterior and posterior midbody, extending posteriorly into the isthmus. Callosal atrophy may possibly reflect a disease‐specific pattern of neurodegeneration and cortical atrophy, fitting well with the predominant impairment of motor functions in the MSA patients. © 2010 Movement Disorder Society

Url:

DOI: 10.1002/mds.23318

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Callosal tissue loss in multiple system atrophy—A one‐year follow‐up study</title>
<author><name sortKey="Minnerop, Martina" sort="Minnerop, Martina" uniqKey="Minnerop M" first="Martina" last="Minnerop">Martina Minnerop</name>
</author>
<author><name sortKey="Luders, Eileen" sort="Luders, Eileen" uniqKey="Luders E" first="Eileen" last="Lüders">Eileen Lüders</name>
</author>
<author><name sortKey="Specht, Karsten" sort="Specht, Karsten" uniqKey="Specht K" first="Karsten" last="Specht">Karsten Specht</name>
</author>
<author><name sortKey="Ruhlmann, Jurgen" sort="Ruhlmann, Jurgen" uniqKey="Ruhlmann J" first="Jürgen" last="Ruhlmann">Jürgen Ruhlmann</name>
</author>
<author><name sortKey="Schimke, Nicole" sort="Schimke, Nicole" uniqKey="Schimke N" first="Nicole" last="Schimke">Nicole Schimke</name>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
</author>
<author><name sortKey="Chou, Yi Y" sort="Chou, Yi Y" uniqKey="Chou Y" first="Yi Y." last="Chou">Yi Y. Chou</name>
</author>
<author><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W." last="Toga">Arthur W. Toga</name>
</author>
<author><name sortKey="Abele, Michael" sort="Abele, Michael" uniqKey="Abele M" first="Michael" last="Abele">Michael Abele</name>
</author>
<author><name sortKey="Wullner, Ullrich" sort="Wullner, Ullrich" uniqKey="Wullner U" first="Ullrich" last="Wüllner">Ullrich Wüllner</name>
</author>
<author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:C1E39B42A7766DA05CF4B632D76A808407CBC10D</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.23318</idno>
<idno type="url">https://api.istex.fr/document/C1E39B42A7766DA05CF4B632D76A808407CBC10D/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000B49</idno>
<idno type="wicri:Area/Istex/Curation">000B49</idno>
<idno type="wicri:Area/Istex/Checkpoint">000B02</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Minnerop M:callosal:tissue:loss</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989455</idno>
<idno type="RBID">PMC:2989455</idno>
<idno type="wicri:Area/Pmc/Corpus">000097</idno>
<idno type="wicri:Area/Pmc/Curation">000097</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000361</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001771</idno>
<idno type="wicri:Area/PubMed/Curation">001771</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001A13</idno>
<idno type="wicri:Area/Ncbi/Merge">002C46</idno>
<idno type="wicri:Area/Ncbi/Curation">002C46</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002C46</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Minnerop M:callosal:tissue:loss</idno>
<idno type="wicri:Area/Main/Merge">002259</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:10-0512941</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000805</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002514</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000B80</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Minnerop M:callosal:tissue:loss</idno>
<idno type="wicri:Area/Main/Merge">002767</idno>
<idno type="wicri:Area/Main/Curation">001E23</idno>
<idno type="wicri:Area/Main/Exploration">001E23</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Callosal tissue loss in multiple system atrophy—A one‐year follow‐up study</title>
<author><name sortKey="Minnerop, Martina" sort="Minnerop, Martina" uniqKey="Minnerop M" first="Martina" last="Minnerop">Martina Minnerop</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Neurosciences and Medicine (INM‐1), Research Centre Jülich, Jülich</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Juliers</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Luders, Eileen" sort="Luders, Eileen" uniqKey="Luders E" first="Eileen" last="Lüders">Eileen Lüders</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of NeuroImaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Specht, Karsten" sort="Specht, Karsten" uniqKey="Specht K" first="Karsten" last="Specht">Karsten Specht</name>
<affiliation wicri:level="1"><country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Biological and Medical Psychology, University of Bergen, Bergen</wicri:regionArea>
<wicri:noRegion>Bergen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department for Clinical Engineering, Haukeland University Hospital, Bergen</wicri:regionArea>
<wicri:noRegion>Bergen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruhlmann, Jurgen" sort="Ruhlmann, Jurgen" uniqKey="Ruhlmann J" first="Jürgen" last="Ruhlmann">Jürgen Ruhlmann</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Medical Center Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schimke, Nicole" sort="Schimke, Nicole" uniqKey="Schimke N" first="Nicole" last="Schimke">Nicole Schimke</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, University Hospital of Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of NeuroImaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chou, Yi Y" sort="Chou, Yi Y" uniqKey="Chou Y" first="Yi Y." last="Chou">Yi Y. Chou</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of NeuroImaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W." last="Toga">Arthur W. Toga</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of NeuroImaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Abele, Michael" sort="Abele, Michael" uniqKey="Abele M" first="Michael" last="Abele">Michael Abele</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wullner, Ullrich" sort="Wullner, Ullrich" uniqKey="Wullner U" first="Ullrich" last="Wüllner">Ullrich Wüllner</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-11-15">2010-11-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">15</biblScope>
<biblScope unit="page" from="2613">2613</biblScope>
<biblScope unit="page" to="2620">2620</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">C1E39B42A7766DA05CF4B632D76A808407CBC10D</idno>
<idno type="DOI">10.1002/mds.23318</idno>
<idno type="ArticleID">MDS23318</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Atrophy (pathology)</term>
<term>Brain Stem (pathology)</term>
<term>Cerebellum (pathology)</term>
<term>Corpus Callosum (pathology)</term>
<term>Corpus callosum</term>
<term>Female</term>
<term>Follow up study</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>MSA</term>
<term>MSA‐C</term>
<term>MSA‐P</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (pathology)</term>
<term>Multiple system atrophy</term>
<term>Nervous system diseases</term>
<term>VBM</term>
<term>corpus callosum</term>
<term>follow‐up</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atrophy</term>
<term>Brain Stem</term>
<term>Cerebellum</term>
<term>Corpus Callosum</term>
<term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term>
<term>Corps calleux</term>
<term>Etude longitudinale</term>
<term>Pathologie du   système nerveux</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Multiple system atrophy (MSA) is a neurodegenerative disease not only affecting the basal ganglia, brainstem, cerebellum, and intermediolateral cell columns of the spinal cord but also the cerebral cortex. Clinically, cerebellar (MSA‐C) and parkinsonian variants of MSA (MSA‐P) are distinguished. We investigated 14 MSA patients (10 MSA‐C, 4 MSA‐P, men: 7, women: 7; age: 61.1 ± 3.3 years) and 14 matched controls (men: 7, women: 7; age: 58.6 ± 5.1 years) with voxel‐based morphometry (VBM) to analyze gray and white matter differences both at baseline and at follow‐up, 1 year later. Baseline comparisons between patients and controls confirmed significantly less gray matter in MSA in the cerebellum and cerebral cortex, and significantly less white matter in the cerebellar peduncles and brainstem. Comparisons of tissue‐loss profiles (i.e., baseline versus follow‐up) between patients and controls, revealed white matter reduction in MSA along the middle cerebellar peduncles, reflecting degeneration of the ponto‐cerebellar tract as a particularly prominent and progressive morphological alteration in MSA. Comparisons between baseline and follow‐up, separately performed in patients and controls, revealed additional white matter reduction in MSA along the corpus callosum at follow‐up. This was replicated through additional shape‐based analyses indicating a reduced callosal thickness in the anterior and posterior midbody, extending posteriorly into the isthmus. Callosal atrophy may possibly reflect a disease‐specific pattern of neurodegeneration and cortical atrophy, fitting well with the predominant impairment of motor functions in the MSA patients. © 2010 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Norvège</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>District de Cologne</li>
<li>District de Giessen</li>
<li>Hesse (Land)</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Bonn</li>
<li>Juliers</li>
<li>Marbourg</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Minnerop, Martina" sort="Minnerop, Martina" uniqKey="Minnerop M" first="Martina" last="Minnerop">Martina Minnerop</name>
</region>
<name sortKey="Abele, Michael" sort="Abele, Michael" uniqKey="Abele M" first="Michael" last="Abele">Michael Abele</name>
<name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name>
<name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name>
<name sortKey="Minnerop, Martina" sort="Minnerop, Martina" uniqKey="Minnerop M" first="Martina" last="Minnerop">Martina Minnerop</name>
<name sortKey="Ruhlmann, Jurgen" sort="Ruhlmann, Jurgen" uniqKey="Ruhlmann J" first="Jürgen" last="Ruhlmann">Jürgen Ruhlmann</name>
<name sortKey="Schimke, Nicole" sort="Schimke, Nicole" uniqKey="Schimke N" first="Nicole" last="Schimke">Nicole Schimke</name>
<name sortKey="Wullner, Ullrich" sort="Wullner, Ullrich" uniqKey="Wullner U" first="Ullrich" last="Wüllner">Ullrich Wüllner</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Luders, Eileen" sort="Luders, Eileen" uniqKey="Luders E" first="Eileen" last="Lüders">Eileen Lüders</name>
</region>
<name sortKey="Chou, Yi Y" sort="Chou, Yi Y" uniqKey="Chou Y" first="Yi Y." last="Chou">Yi Y. Chou</name>
<name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
<name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W." last="Toga">Arthur W. Toga</name>
</country>
<country name="Norvège"><noRegion><name sortKey="Specht, Karsten" sort="Specht, Karsten" uniqKey="Specht K" first="Karsten" last="Specht">Karsten Specht</name>
</noRegion>
<name sortKey="Specht, Karsten" sort="Specht, Karsten" uniqKey="Specht K" first="Karsten" last="Specht">Karsten Specht</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E23 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E23 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:C1E39B42A7766DA05CF4B632D76A808407CBC10D
   |texte=   Callosal tissue loss in multiple system atrophy—A one‐year follow‐up study
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Callosal tissue loss in multiple system atrophy—A one‐year follow‐up study

Callosal tissue loss in multiple system atrophy—A one‐year follow‐up study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.